3,4,5-Trimethoxybenzaldehyde is a white to slightly yellow needle shaped crystal. The molecular formula is C10H12O4, which can be regarded as a trisubstituted product of benzaldehyde and can be used as an intermediate in the organic synthesis of drugs such as trimethoprim.
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99%min |
99.85% |
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5-Br(by GC) |
0.2%max |
0.028% |
What is the synthesis method of 3,4,5-trimethoxybenzaldehyde?
1. It is prepared by methylation and esterification of gallic acid (or tannic acid) with dimethyl sulfate, followed by hydrazinization reaction with hydrazine hydrate, and then oxidation with red blood salt.The yield of industrial production is over 70%.
2. Obtained from vanillin through bromination, hydrolysis, and methylation.
3. Starting from p-nitrotoluene, it undergoes oxidation-reduction, followed by diazotization and hydrolysis with sodium nitrite to obtain p-hydroxybenzaldehyde,Obtained through bromination, dimethoxylation, and methylation.
3,4,5-trimethoxybenzaldehyde can also be prepared from trimethoxybenzonitrile and p-hydroxybenzaldehyde.
3,4,5-trimethoxybenzaldehyde appears as white to slightly yellow needle shaped crystals at room temperature and pressure, as shown in the figure:
Pure 3,4,5-trimethoxybenzaldehyde is an important organic synthetic intermediate. In addition to the synthesis of podophyllotoxin and Tretoxinol, the commonly used antibacterial enhancer trimethoprim (TMP) in the market is obtained by first condensing trimethoxybenzaldehyde with methoxyacrylonitrile to form 3'4'5 '- trimethoxy-2-cyano-3-methoxypropene, which is then cyclized with guanidine nitrate in methanol/sodium methoxide. Experiments have shown that the structure of 3,4,5-trimethoxybenzaldehyde has a good inhibitory effect on Bacillus subtilis, Escherichia coli, Staphylococcus aureus, and Gram negative bacteria (fluorescent Q67)
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3-7 days |
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Suitable for under 50kg. |
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7-15 days |
Suitable for more than 50kg. |
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15-60 days |
Suitable for more than 500kg. |
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