, with a molecular formula of C9H12N Chemicalbook2O4S and a relative molecular mass of 244.26, is a white, odorless crystalline powder that is easily soluble in water and almost insoluble in chloroform, with a melting point of 192-198 degree . It is a synthetic immunostimulant.
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is a representative of chemically synthesized immunostimulants, and its structure is similar to dipeptide. It has the characteristics of anti-toxicity, anti-oxidation, anti-irritation, and anti-infection; it can promote both nonspecific immune responses and specific immune responses. It is mainly used to prevent and treat recurrent respiratory tract infections, chronic bronchitis, recurrent urinary tract infections and other chronic diseases in children, which cause decreased immune function of the organism, and reduce tumor recurrence. The drug has the advantages of rapid distribution and excretion, no accumulation in the body, good tolerance, and no restrictions on the age of applicable patients.
First, L-cysteine (1) and formaldehyde are subjected to dehydration cyclization to obtain L-thiazolidine-4-carboxylic acid (2). L-pyroglutamic acid (3) and pentachlorophenol are reacted in solvent N,N-dimethylformamide (DMF) under the action of condensation agent dicyclohexylcarbonyldiimide (DCC) to obtain L-pyroglutamic acid pentachlorophenol ester (4). Compound (2) and compound (4) are subjected to dehydration condensation under the action of solvent DMF and acid-binding agent triethylamine to obtain pidotimod.
Pidotimod was successfully separated from the endogenous interference in plasma using equal-volume 10 % perchloric acid as protein precipitation agent, and 0.01 M sodium dihydrogen phosphate (pH 4.0 with concentrated phosphoric acid)-methanol-isopropanol (97:2:1, v/v) as mobile phase. After validation of specificity, linearity, recovery, precision, accuracy and stability, this method has been successfully applied to a pharmacokinetic study in rats.
| L-5-Hydroxytryptophan | Greater than or equal to 98.0% | 98.02% |
| 100 % through 80 mesh | ||
| Less than or equal to 1.0 % | 0.73% | |
| Less than or equal to 1.0 % | 0.11% | |
| -34.7~-30.9 degree | -32.5 degree | |
| Less than or equal to 3.0 mg/kg | 0.0276 mg/kg | |
| Less than or equal to 2.0 mg/kg | <0.01 mg/kg | |
| Less than or equal to 1.0 mg/kg | <0.01 mg/kg | |
| Less than or equal to 0.1 mg/kg | 0.0513 mg/kg | |
| Meet Eur.Ph.7.0 <5.4> | ||
| Less than or equal to 10000 cfu/g | 210 cfu/g | |
| Less than or equal to 1000 cfu/g | 10 cfu/g | |
| Non-Irradiation | Less than or equal to 700 | 365 |
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We have confidence in the quality of our products, but if there are any after-sales problems, we will respond as soon as possible and solve them with you in the best way.
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3-7 days |
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Suitable for under 50kg. |
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7-15 days |
Suitable for more than 50kg. |
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15-60 days |
Suitable for more than 500kg. |
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